The 7 PBDE groups assessed were not found to be harmful to human health; however, PBDEs were concluded to be harmful to the environment at levels of exposure at the time of the assessment. About these substances

The critical endpoint of concern for human health is neurobehavioral effects. Various PBDEs have also been studied for ecotoxicity in mammals, birds, fish, and invertebrates. In some cases, current levels of exposure for wildlife may be at or near adverse effect levels.

Lower-brominated PBDEs have been known to affect hormone levels in the thyroid gland. Studies have linked them to reproductive and neurological risks at certain concentrations or higher. Even though there is little information on the health effects of PBDE exposure, it is still of concern to humans because some types of PBDEs can build up in the fatty tissues of the body and in breast milk. ENVIRONMENTAL HEALTH – CONTAMINANTS FACT SHEETS If you would like this information in another official language, contact us at 1-855-846 Exposures and health effects PentaBDE may enter the body by ingestion or inhalation.

Polybrominated diphenyl ethers (PBDEs) are used as flame retardants in plastics (concentration, 5--30%) and in textile coatings. Commercial products consist predominantly of penta-, octa-, and decabromodiphenyl ether mixtures, and global PBDE production is about 40,000 tons per year. PBDE Toxicology (selected, mostly rats & mice, depends on congener) endocrine disruption thyroid anti-androgen (OH-metabolites?) developmental neurotoxicology reproductive effects ovarian changes decreased sperm, epididymis weight delayed puberty Some effects seen at levels not that different from those found in some people. (PBDE-47 and -99 are each major constituents of commercial PBDE mixtures used widely in North America.) These effects were persistent and became more pronounced as the mice aged [Eriksson 2001 and 2002]. The chemicals -- called polybrominated diphenyl ethers, or PBDEs -- are everywhere: in your TV, your computer, your toaster and your sofa.

commonly found in humans. Recent concerns on possible adverse health effects of PBDEs are focusing on their potential endocrine disrupting effects and on developmental neurotoxicity.

"In order to Development of health-related environmental monitoring in the City of Stockholm Many environmental problems are only detected when the damage of a commercial polybrominated diphenyl ether (PBDE) preparation, 1 Sofiev et al., 2018. Cleaner fuels for ships provide public health benefits with climate trade-offs.

to elevated levels of polycyclic aromatic hydrocarbons (PAHs) and trace organic compounds (e.g. PCB, OCP, PBDE) can be related to negative health effects.

was used to assess the health risk of dietary PBDE exposure in this study. The MOE is calculated by dividing the dose at which adverse effects were observed in laboratory animal studies by the estimated exposure to PBDEs from food. The lower the MOE, the greater is the public health risk. The calculated MOE values (38,000 for average Based on studies on experimental animals, the toxicological endpoints of exposure to PBDEs are likely to be thyroid homeostasis disruption, neurodevelopmental deficits, reproductive changes, and even cancer.
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These studies observed problems with learning, memory, and behavior in mice and rats. Animal studies also found that PBDEs can alter thyroid and other hormone levels. The critical endpoint of concern for human health is neurobehavioral effects. Various PBDEs have also been studied for ecotoxicity in mammals, birds, fish, and invertebrates.

Identification and Characterisation of Hydroxylated PCB and PBDE Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH miljö- och hälsoriskbedömning av den f.d. plantskolan vid Kårehogen, Orust kommun. Kraven är att god kemisk status ska uppnås, med undantag av Hg och PBDE för vilka halterna Human health risk assessment protocol for hazardous.
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This fact sheet answers the most frequently asked health questions (FAQs) about PBDEs. For more information, call the ATSDR Information Center at 1-888-422-8737. This fact sheet is one in a series of summaries about hazardous substances and their health effects. It is important you understand this information because these substances may harm you.

Many potential adverse health effects have been reported due to exposure to PBDEs, i.e., endocrine disruption, reproductive and developmental toxicity, central nervous system effects, and immune system impact [ 1 - 3 ]. PBDEs do not easily degrade in the environment and many of the congeners have relatively long half-lives in the body [ 4 ]. In addition to these concerning PBDE-related effects on human health, another serious worry is their neurotoxicity and potential roles in the etiology of neurodevelopmental disorders. A substantial amount of work has been done, surveying the potential association of PBDE exposures with behavioral deficits in humans, as well as in other animal models. Polybrominated diphenyl ether (PBDE) flame retardants have been routinely added to consumer products for several decades in a successful effort to reduce fire-related injury and property damage. Global production of PBDEs has reached 67,000 metric tons per year. Recently concern has arisen because of the widespread occurrence of several classes of BFRs in the environment and in human biota.